Douglas Sanchez: Interesting study to take into account, I

The statin cold stone family of drugs as have the property reduce cholesterol levels through its inhibitory effect on HMG-CoA reductase. The achieved reduction in levels of LDL cholesterol and other atherogenic forms in multiple studies has impacted positively on cardiovascular risk (1). There are seven formulations (lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, rosuvastatin and pitavastatin) which differ from each other by the power of its lipid-lowering effect and the frequency of adverse effects. But in addition to its effects on lipids, also have other promising pharmacodynamic cold stone actions include improved endothelial function, reduced vascular inflammation and platelet aggregation, antithrombotic action, stabilization of atherosclerotic plaques, increased neovascularization of ischemic tissues, increased fibrinolysis and immune suppression (1).
All this is fine, but why think prescribe statins to everyone? Sounds a bit risky, but it has been accepted for publication in the British Journal of Dermatology an article that makes us think we could become so. The article can be found at: Br J Dermatol cold stone 2014 February 7; [E-pub ahead of print].
In this paper, the authors study, a randomized, double-blind and placebo compared to the effects of simvastatin on the management of venous ulcers. Venous insufficiency is a major cause of leg ulcers and their treatment is often difficult. The primary treatment is compression, but benefits have been reported previously with low-dose aspirin (2), pentoxifylline (3) and even with topical beta-blockers (4). To date there were animal cold stone studies data on the potential benefit of statins in wound healing (5), but there were no human data.
The authors then compared cold stone to simvastatin 40 mg orally against standard management in 66 patients with non-infected ulcers under 10 cm in diameter. Thirty-two patients were assigned to the simvastatin group and 34 to the control group. He followed them for ten weeks. In patients with ulcers less than 5 cm in diameter, 100% of the simvastatin group had healing, against only 46% in the control group (0.11 RR, 95% CI: 0.02 to 0.77). Furthermore, the healing time was too short (about two weeks). cold stone In the total group, 72% of patients in the simvastatin group achieved healing, whereas the control group, only 32%. There were no differences in toxicity between the two groups.
Although a small study, as proof of concept, should make us think of performing cold stone larger studies to confirm whether statins also should be an integral part of the management of venous ulcers of the lower limbs.
Douglas Sanchez: Interesting study to take into account, I'm still reluctant to leave all their statin liver toxicity and do not see the utility in patients cold stone older than 70 years. But this opens new possibilities. One teacher said you're not the first to embrace cold stone a new technique cold stone but never be the last.
Thanks for the feedback. As for the risk of liver toxicity has been shown that they are hepatoprotective, however, should be aware of any eventuality with patients and select those who will benefit most from therapy.
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